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Anna University Chennai

Principal Investigator: Dr Suvro Chatterjee

Dr. Suvro Chatterjee has contributed significantly to the biology of nitric oxide in general and in the context of angiogenesis in particular. His core contribution in angiogenesis research is the establishment and elaboration of model for early angiogenesis, known as “Endothelial Ring”, which is the nascent structural monomer for a blood vessel (Sinha et al., European Journal of Cell Biology, 2010, in press). Further, Chatterjee and his group has described a novel cross talk between the “orphan drug” thalidomide and nitric oxide signaling in the endothelium via soluble guanylate cyclase–cGMP cascade.

Recently Dr. Chatterjee has discovered the anti-angiogenesis property of sFRP4, a mediator of Wnt signalling, for which a patent is in progress and could lead to the development of a new anti-cancer peptide drug. Other research has explained the biology behind nitric oxide based recovery from high altitude induced pulmonary edema (HAPE). An organosulfur drug has been identified which significantly reduces the edema formation by activating NOS in experimental animal lungs under hypobaric hypoxia.

Dr. Chatterjee has also been highly successful in developing assays and models, with core importance in vascular biology. He recently has introduced a novel partial ischemia model using Chicken Chrioalantoic Membrane (CAM), which significantly reduces the time and cost of anti-stroke drug development along with substantial reduction in the number of animal sacrificed in stroke research (Majumder et al., PLoS One in 2010). Dr. Chatterjee’s recent work in inciting angiogenesis under simulated microgravity is a great advance for the development of Tissue Engineered Blood Vessels (TEBV). Staff also qualified for prestigious national and international research awards, travel fellowships and scholarships such as Wood-Whelan Fellowship (IUBMB), Boheinger Fellowship (European Union), N.K. Ganguly Award (International Heart Society), and the University of Western Australia research award. As well as collaborations across India, collaborations are established with groups in Australia (Western Australia, Sydney), Switzerland (University of Berne), and the USA (Mayo Clinic, Medical College of George, NIH and the Wistar Institute).

1. Sinha S, Sridhara SRC, Srinivasan S, Muley A, Majumder S, Kuppusamy M, Gupta R, Chatterjee S. (2011) NO (Nitric oxide): The Ring Master. Eur. J. Cell Biol. 90(1):58-71.

2. Siamwala JH, Majumder S, Tamilarasan KP, Muley A, Seerapu HR, Kolluru GK, Sinha S, Chatterjee S. (2010) Simulated microgravity promotes nitric oxide-supported angiogenesis using the iNOS-cGMP-PKG pathway in macrovascular endothelial cells. FEBS Letter, 584 (15):3415-3423.

3. Majumder S, Ilayaraja M, Seerapu HR, Sinha S, Siamwala JH, Chatterjee S. (2010) Chick embryo partial ischemia model: a new approach to study ischemia ex vivo. PLoS One. 7;5(5):e10524.

4. Kolluru GK, Sinha S, Majumder S, Muley A, Siamwala JH, Gupta R, Chatterjee S. (2010) Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis. Nitric Oxide. 2010;22(4):304-315.

5. Muley A,  Majumder S, Kolluru GK, Parkinson S, Viola H, Hool L, Arfuso F, Ganss R, Dharmarajan A , Chatterjee S (2010) Secreted Frizzled-Related Protein 4: An Angiogenesis Inhibitor. . Am J Pathol. 2010;176(3):1505-16.

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