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University of L'Aquila

Principal Investigator: Professor Anna Maria Teti

The Bone Biopathology Laboratory in the Department of Biotechnological and Applied Clinical Sciences investigates the mechanisms of bone disease including osteoporosis, bone metastasis and rare genetic conditions. Prof. Anna Maria Teti has a long-standing expertise in bone cell biology with an internationally established reputation. In vitro and in vivo studies have a special emphasis on the mechanisms of bone remodelling. Antiresorptive agents are being tested to prevent or cure bone metastases and osteoporosis in experimental animals. Recent work analysing the osteoblast transcriptome under microgravity has identified a novel signalling molecule involved in osteoblast metabolism and osteoblast-osteoclast cross-talk.

Professor Teti has long experience of international research collaboration both with groups in USA (Gerard Karsenty), Sweden, Germany, France, Belgium and the UK. The group has participated in FP6 projects MetaBre (as coordinator) and OSTEOGENE. Professor Teti is internationally known in the field of bone research having held senior positions of responsibility in the European Calcified Tissues Society, International Bone and Mineral Society and the American Society for Bone and Mineral Research.

1. F. De Benedetti, N. Rucci, A. Del Fattore, B. Peruzzi, R. Paro, M. Longo, M. Vivarelli, F. Muratori, S. Berni, P. Ballanti, S. Ferrari, A. Teti: Impaired skeletal development in interleukin-6 transgenic mice. A model for the impact of chronic inflammation on the growing skeletal system. Arthr. Rheum. 54:3551-3563, 2006.

2. M. Capulli, A. Rufo, A.Teti, N. Rucci. Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a “mechanoresponsive osteoblast gene signature”. J. Cell Biochem, 107:240-252, 2009.

3. T. Schinke, A.F. Schilling, A. Baranowsky, S. Seitz, R.P. Marshall, T. Linn, M. Blaeker, A.K. Huebner, A. Schulz, R. Simon, M. Gebauer, M. Priemel, U. Kornak, S. Perkovic, F. Barvencik, F.T. Beil, A. Del Fattore, A. Frattini, T. Streichert, K. Pueschel, A. Villa, K.M. Debatin, J.M. Rueger, A. Teti, J. Zustin, G. Sauter, M. Amling. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med. 15:674-681, 2009.

4. N. Rucci, A. Rufo, M. Alamanou, M. Capulli, A. Del Fattore, E. Åhrman, D. Capece, V. Iansante, F. Zazzeroni, E. Alesse, D. Heinegård, A. Teti. The glycosaminoglycan binding domain of PRELP acts as a cell type-specific NF-kB inhibitor that impairs osteoclastogenesis. J. Cell Biol., 187 669-683, 2009.

5. M Ferron, J Wei, T Yoshizawa, A Del Fattore, RA Depinho, A Teti, P Ducy, G Karsenty. Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism. Cell. 142:296-308, 2010

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