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Marie Curie fellows

INTERBONE is supporting exchanges of young scientists betwen the partners. On this page we profile our Marie Curie Fellows that have participated in the visits.

From University of L'Aquila


Dr Mattia Capulli recently worked on a large scale transcriptome analysis of osteoblasts subjected to simulated microgravity as the most upregulated gene compared to controls. He has expertise in bone cell biology, mouse bone phenotyping, gene profiling analysis and elaboration of data by bioinformatics and biostatistics. In INTERBONE, Dr Capulli undertook a 6 month visit to Columbia University. He learned how to generate conditional animal models and investigate the relationship between bone and energy metabolism.

Sara Gemini Piperni is a PhD student at UNIVAQ. She recently characterized the bone phenotype of ASC KO mice to investigate a potential relationship between inflammasome and bone. She has expertise on in vitro cultures of mouse and human osteoclasts and osteoblasts and their phenotyping, and applies cell and molecular biology techniques. Within the INTERBONE project, Sara travelled to Brazil, to learn how to perform in vitro studies on biomaterial osteointegration in the laboratory headed by Dr. Willian Zambuzzi. She has also visited the UNIVANNA group for training in functional assays using endothelial cells.

Riccardo Paone is a research technician, student in the laboratory headed by Prof. Anna Maria Teti at University of L'Aquila. He has expertise in bone histology and histomorphometric analysis. He performs in vivo experiments and contribute to studies aimed at investigating new treatments for bone diseases. In INTERBONE he will visit the laboratory headed by Prof. Gerard Karsenty at Columbia University, NY, USA, to learn how to generate conditional animal models and contribute to functional assays especially focused on the relationship between bone and energy metabolism.

Antonio Maurizi is a student in Medical Biotechnology and a research technician in the Bone Biopathology Laboratory headed by Prof. Anna Maria Teti at the University of L'Aquila. He has expertise in bone histology, mouse bone phenotyping and µCT analysis. He recently collaborated in the characterization of the bone phenotype of an animal model of autosomal dominant osteopetrosis generated in the Bone Biopathology Laboratory, and he is currently contributing to studies aimed at investigating new treatments for genetic bone diseases. In INTERBONE he will visit the laboratories headed by Prof. Gerard Karsenty and Prof. Stavroula Kousteni at Columbia University, NY, USA, to learn functional assays focused on the relationship between bone and energy metabolism.


Marco Ponzetti is a research technician in the “Bone Biopathology lab” headed by Prof. Anna Teti. He has recently investigated the role of oxygen binding globins (especially HBB, beta globin) in determining a more invasive and metastatic phenotype in breast cancer cells both in vitro and in vivo. He has expertise in molecular and cell biology, especially in RNA and cell-based assays. He also performs ucT analyses in both long bones and vertebrae. He works with transgenic animal models reproducing bone pathologies as well, and is being trained in bone histology. In INTERBONE he will undertake a 5-month visit to the laboratory headed by Prof. Stavroula Kousteni at Columbia University, NY, USA. During his visit he will be trained on the generation of transgenic mouse models with targeted overexpression of secreted factors in osteolineage cells.

 

From ERASMUS MC

Andrea Brum is a PhD student in the laboratory of Professor Hans van Leeuwen. She is investigating the process of mesenchymal stem cell differentiation toward osteoblasts with an emphasis on identifying novel factors involved in the osteoblast lineage decision making process. She has expertise on in vitro and in vivo bone formation models. In INTERBONE she travelled to Columbia University for training on generation of animal models.

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Niken Adisty is a research techician in the laboratory of Dr. Marc Raaijmakers. She is involved in the ongoing study of the role of bone marrow microenvironment in hematopoiesis and blood diseases. According to the Interbone program she travelled to Anna University Chennai for a period of 3 months, to study the effect of microgravity on endothelial cells and angigenesis under the supervision of Dr. Suvro Chatterjee.

Bram van der Eerden has studied a range of mouse and rat models but also human genetic cases related to calcium, cartilage and bone metabolism. He has expertise in human and mouse bone cell culture systems, murine bone phenotyping, histomorphometry, transcriptome as well as small RNA expression analysis of human bone cells. Moreover, he is involved in human genetic cases involving rare mutations  in calcium- and bone-related genes but also DNA polymorphism studies at population level. Within INTERBONE, Dr van der Eerden will undertake one visit to Columbia University and one to Universidade do Grande Rio to gain knowledge on mouse genetics and the application of biomaterials in several in vitro and in vivo bone formation models.

Marta Baroncelli is a PhD student in the laboratory of Prof. Hans van Leeuwen, Erasmus MC. She is focused on the role of mesenchymal stromal cells (MSCs) to enhance bone regeneration, and especially the interplay with the extracellular matrix to enhance MSC osteogenic differentiation, as well as the potential role of MSC-derived extracellular vesicles. Within INTERBONE she will visit the laboratory of Prof. Zambuzzi in UNESP for 2 months to learn about intracellular signalling of cellular adhesion to matrices and to develop improved biomaterials for tissue regeneration.

From Universidade do Grande Rio and Universidade Estadual Paulista at Botucatu

Suelen Cristina Sartoretto is dentist and nowadays she is attending the master degree at Dental Sciences in Universidade Federal Fluminense, located at Niterói (Rio de Janeiro, Brazil). She is working in collaboration with Professor Zambuzzi's group (at UNESP) on a biocompatibility and bioresorption of biomaterials, particularly using nanostructures of carbonated hydroxyapatite, synthesized at different temperatures and then implanted subcutaneously in animal models. She has expertise in surgery animal models, histological and histomorfometric analysis. In agreement with INTERBONE project she will visit UNIVAQ for 4 months in order to study the interaction of biomaterials in different animal models and to learn how to work using primary culture of osteoblasts and osteoclasts.

Juliana Alves Côrtes is currently completing a Masters degree in Biotechnology at the Fluminense Federal University (UFF, Niterói, Brazil), studying the biological response of primary human osteoblastos to different nanostructured hydroxiapatite-based biomaterials. In her doctoral project, under the co-supervision of Dr. Zambuzzi (UNESP), she will investigate the role of protein phosphatases on the regulation of osteoblast and osteoclast behaviour. She will visit UNIVAQ for 12 months, in order to train on knockout animal models and perform studies on osteoclastogenesis.

Flávia Amadeu de Oliveira is Biologist and is currently a PhD student at University of São Paulo (Bauru Dental School, FOB-USP, Bauru, Brazil), under the direct supervision of Prof. Rodrigo Cardoso de Oliveira, Prof. Camila Peres Buzalaf and Prof. William Zambuzzi. Over the last years, Ms. Flávia investigated the role of trophic molecules in promoting osteoblast differentiation, focusing on identifying new molecules as therapeutic tool for bone patologies. Moreover, the Brazilian group is expert in biomaterials able to support bone regeneration. Ms Flávia works with cell culture, molecular biology and biochemistry approaches. According to INTERBONE she will visit the laboratory headed by Prof. Dr. Anna Maria Teti of UNIVAQ for 11 months in order to study bone biology, mainly osteoblast behavior and osteoclastogenesis.

Adriana Arruda Matos is Biologist and currently a PhD student at University of São Paulo supervised by Prof. Rodrigo Cardoso de Oliveira (Bauru Dental School, FOB-USP, Bauru, Brazil) and Prof. Willian Fernando Zambuzzi (UNESP-Botucatu, Brazil), identifying properties of ANKH protein during in vitro mineralization. On the last few years, Ms. Adriana worked with biomaterials than can modulate the behavior of osteoblast cells and natural molecules involved in osteoblast differentiation. According to INTERBONE, she is visiting the laboratory headed by Prof. Hans van Leeuwen of Erasmus MC for 11 months in order to study the function of the CD24+ and CD24 - in hMSC differentiated into osteoblasts/adipocytes and in non-differentiated cells and to study ANKH and interacting proteins in the context of osteoblast differentiation and mineralization. Ms Adriana and our group in Brazil are very excited with this opportunity.


Dr Willian Zambuzzi is assistant professor at State University of São Paulo (UNESP), campus Botucatu, São Paulo Brazil. His research group has worked in establishing a metabolic atlas of signaling proteins activated during osteoblast adhesion in order to assist the materials scientist to develop smart materials. The diversity of proteins affected suggests that understanding the events involved in cytoskeletal organization in response to different biomaterials may yield an informed design platform/rationale for the future development of novel biomaterials. Within INTERBONE project, Dr. Zambuzzi undertook a 3 week visit to ERASMUS in April/May 2015  to learn how generate global arrays of kinases and how to perform extracellular vesicles studies.

From Anna University Chennai

Mr. Pradeep Thangaraj is a research fellow in the laboratory of Dr. Suvro Chatterjee Anna University. He has expertise in endothelial cell biology, gene profiling analysis, and protein docking studies. He visited the University of L’Aquila to study the role of co-culture (endothelium and osteoblast) in bone repair mechanism under simulated microgravity.

Dr. Uttara Saran has recently worked on understanding molecular mechanisms governing angiogenesis in both in vitro and ex ovo based models. She has expertise in cancer and endothelial cell biology, gene sequencing and angiogenesis assays. In INTERBONE, Dr. Saran visited Erasmus MC, The Netherlands, for a period of 3 months, to study the interaction of microenvironmental (stromal, endothelial) cells and hematopoietic stem cells in in vitro culture systems.


Mr. Vimal Veeriah is a Phd Student in the laboratory of Dr. Suvro Chatterjee, at Anna University. Currently he is working on the nitric oxide implications on embryonic development with emphasis teratogenic effects on cardiovascular and limb development. He will be visiting the University of L’Aquila for a period of 12 months under the INTERBONE exchange programme. He will be trained in bone cells culture, animal models and microgravity experiments.


Dr. Reji Manjunathan is presently working on leptin/eNOS axis in endothelium in the laboratory of Dr. Suvro Chatterjee. She has expertise in biochemical, biophysical, gene profiling and angiogenic assays, which include both in vitro and ex ovo models. Dr. Reji will be visiting University of L’Aquila for a period of 5 months under the INTERBONE exchange programme. She will be trained in bone cells culture, animal models pertaining to bone repair mechanism.

 

Mr. Jyotirmaya Behera is a PhD student in the laboratory headed by Dr. Suvro Chatterjee at Anna University. He is focused on the differentiation of endothelial progenitor cells (EPCs) under low oxygen environments, as well as the molecular regulation of hypoxia diminished endothelial progenitor/stem cells (EPC) adhesion to extracellular matrix by Integrin alpha5beta1 in relation with nitric oxide signaling. In addition, he is working on denotative effect of anti-breast cancer drugs on cardiovascular dysfunctions. Within INTERBONE programme he will visit the laboratory of Prof. Hans van Leeuwen in University of Erasmus Medical centre for 11 months to learn about cross-talk signaling mechanisms of bone cells with endothelial cells by co-culture model and to develop improved blood vessel pattern for effective tissue regeneration.